Introduction
The skin barrier has long been an invisible hero in our overall health and beauty, yet it remains one of the most misunderstood aspects of skincare. For years, the conversation around skin health has revolved around moisturizers, serums, and external products that promise to transform the surface of the skin. Advertisements often convince us that glowing, youthful skin lies inside a jar of cream or a bottle of oil. However, the real secret to strong, radiant, and healthy skin begins deeper — within the very structure of the skin barrier itself. Understanding what this barrier is, how it functions, and why it fails is essential for anyone seeking not just cosmetic beauty but genuine skin health.
The concept of the skin barrier is not new in dermatology, but it has gained significant attention in recent years as more people struggle with issues like sensitivity, dryness, acne, eczema, and inflammation. These problems often lead consumers to try new moisturizers or treatments in hopes of repair, but few realize that the most effective solution is often not about adding more layers of product — it’s about supporting and restoring the skin barrier from the inside out. The skin barrier, also known as the stratum corneum, serves as the body’s frontline defense system. It is the interface between our internal environment and the external world — a dynamic shield that determines how well our skin can retain moisture, fend off irritants, and maintain overall resilience.
In this exploration, we will look deeper into what the skin barrier truly is, how it works, and what factors damage it. We will also discuss why internal health, nutrition, and lifestyle habits play a more crucial role in maintaining the skin barrier than topical products alone. By the end, it will become clear that while moisturizers are useful, they are not the true foundation of healthy skin — the strength of the skin barrier is.
1. The Anatomy of the Skin Barrier: Nature’s Protective Shield
To understand why the skin barrier is more important than your moisturizer, one must first understand what it actually is. The term “skin barrier” refers primarily to the stratum corneum, which is the outermost layer of the epidermis. Although it is only about 10 to 20 micrometers thick — thinner than a sheet of paper — it performs a function so critical that life without it would be impossible. This layer acts as a biological barrier, preventing excessive water loss from within while simultaneously protecting the body from external aggressors such as bacteria, allergens, pollution, and toxins.
The stratum corneum is often described using the “brick-and-mortar” model. In this analogy, the “bricks” are corneocytes (dead skin cells filled with keratin), while the “mortar” is composed of a complex mix of lipids, including ceramides, cholesterol, and fatty acids. Together, these structures form a highly organized matrix that keeps the skin resilient, flexible, and hydrated. When this matrix is intact, the skin appears smooth, plump, and radiant. When it’s disrupted, the skin becomes dull, rough, and prone to irritation.
Beneath the stratum corneum lies the living epidermis, where new skin cells are continuously produced. These cells gradually move upward, undergoing a process called keratinization, before eventually dying and becoming part of the protective outer layer. This cycle ensures that the barrier renews itself every 28 to 40 days, depending on factors such as age, nutrition, and hormonal balance.
What makes the skin barrier so fascinating is its intelligence. It’s not just a static shield; it’s a responsive and adaptive system. When the environment becomes dry, the skin barrier increases lipid production and retains more moisture. When exposed to pathogens, it triggers immune responses through specialized cells called Langerhans cells. In short, the barrier acts as both a physical and immunological defense, coordinating protection on multiple levels.
Moisturizers, though beneficial, often act as temporary bandages that seal in water. They cannot replace or rebuild a damaged barrier if the body lacks the internal resources — lipids, proteins, hydration, and nutrients — required for proper barrier synthesis. This distinction is crucial because it explains why people can use high-end creams yet still experience dryness or irritation: the surface is hydrated, but the underlying structure remains weak.
A well-functioning skin barrier maintains an ideal acid mantle, typically with a pH between 4.5 and 5.5. This slightly acidic environment discourages harmful bacteria from thriving while supporting the growth of beneficial microflora. When the pH is disrupted — through over-cleansing, harsh exfoliants, or poor diet — the protective function diminishes, leading to breakouts, sensitivity, and chronic inflammation. The harmony of lipids, hydration, and pH forms the essence of skin integrity.
The human skin barrier is, therefore, not simply a wall; it’s an ecosystem. And like any ecosystem, its health depends on balance. If any component — be it lipid, protein, or hydration — is out of equilibrium, the whole system suffers.
2. Factors That Damage the Skin Barrier
The modern lifestyle is one of the greatest threats to the skin barrier. From constant exposure to pollution and ultraviolet radiation to the use of harsh cleansers and overly aggressive skincare routines, we are continuously compromising the very layer that protects us. The irony is that many of the practices people believe will improve their skin — frequent exfoliation, strong acids, and trendy treatments — often do the opposite.
Environmental factors play a leading role in barrier disruption. Air pollution exposes the skin to free radicals and particulate matter that can penetrate the upper layers and trigger oxidative stress. This weakens the lipids in the stratum corneum, leading to dehydration and inflammation. UV radiation is another major offender, breaking down collagen, elastin, and ceramides, thereby increasing transepidermal water loss (TEWL). Over time, chronic sun exposure leads to premature aging and barrier dysfunction.
Over-cleansing is a particularly common mistake. Many people use foaming cleansers or soaps that strip away natural oils. While this may give the temporary feeling of “clean skin,” it also removes the lipid layer necessary for moisture retention. Similarly, excessive exfoliation — whether through scrubs or chemical acids — can thin the stratum corneum, exposing the more delicate layers underneath.
Another overlooked factor is temperature and humidity. The skin barrier performs optimally in a moderately humid environment. In very dry climates or during winter, indoor heating and cold air combine to reduce humidity drastically, leading to increased TEWL. This is why many people experience flakiness or irritation during colder months despite using the same moisturizer.
But the damage isn’t just external — internal factors can be just as destructive. Diet, stress, lack of sleep, and hormonal imbalance all influence the skin barrier’s ability to function. A diet low in essential fatty acids, such as omega-3 and omega-6, can impair lipid production, weakening the mortar that holds the barrier together. Chronic stress elevates cortisol levels, which suppresses skin repair mechanisms and increases inflammation. Meanwhile, dehydration from insufficient water intake directly reduces the skin’s ability to maintain hydration levels.
Furthermore, skin disorders such as eczema, psoriasis, and rosacea are all associated with a compromised skin barrier. In these conditions, genetic and environmental factors combine to create an impaired lipid matrix and increased permeability. This means irritants can easily enter while water escapes more readily, setting off a vicious cycle of inflammation and sensitivity.
Interestingly, even skincare products designed to “repair” the barrier can sometimes worsen the situation. Formulas containing alcohol, fragrance, or harsh preservatives can irritate sensitive skin. The beauty industry’s obsession with instant results often pushes consumers toward overuse of active ingredients like retinoids or acids, which — when not properly balanced — disrupt the barrier rather than strengthen it.
In short, the modern lifestyle, while offering endless beauty solutions, often undermines the very foundation of healthy skin. The true challenge is learning how to protect the barrier not just from external assaults but from our own habits and choices.
3. Nourishing the Skin Barrier from Within
While topical treatments can help restore the surface of the skin, true and lasting repair starts from within. The skin barrier, like any other organ system, depends on proper nutrition, hydration, and cellular function. What we eat, how we sleep, and the level of stress we experience all have a profound impact on the structure and resilience of the stratum corneum.
Nutrition is one of the most powerful — yet underestimated — tools for maintaining a strong skin barrier. The lipids that form the barrier’s “mortar” come primarily from fatty acids synthesized in the body. Essential fatty acids (EFAs), including omega-3 and omega-6, are not produced internally and must come from diet. Foods rich in EFAs — such as salmon, walnuts, flaxseed, and chia seeds — support the production of ceramides and cholesterol, ensuring the skin retains moisture effectively.
Vitamins and minerals are equally vital. Vitamin A (retinol) supports cell turnover and repair; vitamin C aids collagen synthesis and acts as an antioxidant, protecting against oxidative stress; vitamin E stabilizes cell membranes; and zinc helps regulate inflammation and healing. Together, these nutrients fortify the skin’s ability to repair itself and resist damage.
Hydration is another cornerstone. Water is essential for every cellular function, and dehydration immediately impacts skin health. Drinking enough fluids helps maintain optimal intracellular water balance, reducing TEWL and improving elasticity. However, hydration isn’t just about water intake — electrolytes such as potassium and magnesium are necessary to help cells retain that water effectively.
The gut-skin axis has emerged as a major area of research in dermatology. The gut microbiome — the community of microorganisms living in our digestive system — plays a direct role in inflammation, immune regulation, and nutrient absorption. An imbalanced gut microbiome can lead to systemic inflammation that manifests as acne, eczema, or barrier dysfunction. Probiotics, prebiotics, and fiber-rich diets promote a healthy gut, which in turn enhances skin resilience.
Sleep and stress management are equally crucial. During deep sleep, the body undergoes repair processes, including skin regeneration and lipid synthesis. Chronic sleep deprivation reduces these restorative phases, weakening the barrier. Stress, on the other hand, elevates cortisol, which breaks down collagen and delays wound healing. Practices such as mindfulness, yoga, and regular physical activity can mitigate these effects, supporting both mental and skin health.
In short, a moisturizer can hydrate the outer layer, but only a well-nourished body can build and maintain a healthy barrier from within. The internal environment sets the foundation upon which any external product must work.
4. Strengthening and Sustaining the Skin Barrier: Beyond Moisturizers
Once the importance of the skin barrier is understood, the next step is learning how to protect and strengthen it — both inside and out. While internal nourishment forms the foundation, external care can provide valuable support when done correctly.
A gentle skincare routine begins with cleansing — one of the most misunderstood steps. The goal is not to strip the skin but to remove impurities while maintaining the natural lipid layer. Cream or oil-based cleansers with low pH formulations are ideal because they preserve the acid mantle. Overwashing or using hot water disrupts this delicate balance, so it’s best to cleanse with lukewarm water and minimal friction.
Next comes moisturizing, which should be thought of as reinforcement rather than repair. A good moisturizer mimics the skin’s natural lipid composition — containing ceramides, cholesterol, and fatty acids in balanced ratios. These ingredients help replenish what the barrier naturally loses due to age, environment, or stress. Humectants such as hyaluronic acid and glycerin draw water into the upper layers, while occlusives like squalane or shea butter prevent moisture loss.
However, skincare doesn’t stop at hydration. Barrier-repair treatments are now an integral part of advanced dermatology. Ingredients like niacinamide strengthen the barrier by increasing ceramide production and reducing inflammation. Panthenol and allantoin promote healing and soothe irritation, while urea aids in both exfoliation and hydration. These ingredients work synergistically to enhance the natural function of the skin barrier rather than simply coating it.
Sun protection is another non-negotiable. Ultraviolet light is one of the most potent enemies of the skin barrier, breaking down lipids and collagen while triggering oxidative stress. Daily use of a broad-spectrum sunscreen, even on cloudy days, prevents cumulative damage that leads to premature aging and barrier dysfunction.
Beyond topical products, lifestyle habits can make or break the barrier. Smoking, for example, constricts blood vessels and depletes vitamin C, impairing collagen synthesis. Excessive alcohol consumption dehydrates the body and increases inflammation. Meanwhile, consistent exercise enhances circulation, ensuring skin cells receive sufficient oxygen and nutrients for repair.
A balanced approach also requires understanding your skin’s natural rhythm. Overloading it with products can be counterproductive. The minimalist skincare movement, which emphasizes using fewer but more effective products, aligns perfectly with barrier health. The goal is not to overwhelm the skin with actives but to support its own intelligent systems of repair and renewal.
For those dealing with chronic skin issues, dermatological guidance is invaluable. Conditions like eczema, rosacea, or persistent sensitivity often require medical-grade formulations or prescribed treatments. Dermatologists can identify whether the problem lies in lipid deficiency, inflammation, or microbiome imbalance and tailor a regimen that restores the barrier without overburdening it.
Finally, long-term maintenance means thinking of skin care as skin health care. Just as we nourish our body through balanced diet and rest, the skin requires consistent attention to internal and external balance. The moisturizer you apply may give temporary relief, but it is the daily habits — sleep, nutrition, stress management, and gentle care — that sustain the barrier’s strength.
5. The Role of Microbiome in Skin Barrier Health
The human skin is not just a passive surface but a living habitat for an immense variety of microorganisms collectively known as the skin microbiome. This invisible community of bacteria, fungi, and viruses lives symbiotically with us, contributing significantly to the function and resilience of the skin barrier. Far from being harmful, most of these microbes play a protective role — regulating inflammation, training the immune system, and preventing the colonization of pathogenic species. The balance between the microbiome and the barrier is so intricate that disrupting one almost inevitably harms the other.
The skin’s microbiome varies across body regions — the oily forehead and scalp host different populations than the dry arms or moist underarms. This diversity ensures that each microenvironment maintains stability against external stressors. The microbiome produces antimicrobial peptides, short-chain fatty acids, and enzymes that help maintain the skin’s slightly acidic pH. This acidic environment, known as the acid mantle, prevents the overgrowth of harmful bacteria and preserves lipid integrity.
When the microbiome is disrupted — a state known as dysbiosis — the effects can be profound. Overuse of antibacterial soaps, frequent cleansing, or the application of harsh products strip away beneficial microbes, leaving the skin vulnerable. Dysbiosis contributes to numerous skin conditions such as acne, eczema, seborrheic dermatitis, and rosacea. In eczema, for instance, studies have shown that the overgrowth of Staphylococcus aureus occurs alongside reduced microbial diversity, amplifying inflammation and weakening the barrier.
Supporting the skin microbiome begins with gentle care and respect for its natural ecology. Avoiding harsh cleansers, alcohol-based toners, and overuse of exfoliants helps preserve microbial balance. Ingredients like prebiotics (which feed beneficial bacteria) and probiotics (which introduce beneficial strains) are becoming increasingly popular in skincare formulations. These compounds help restore harmony on the skin’s surface, enabling the microbiome to perform its natural protective functions.
Diet and lifestyle also influence microbial health. A diet rich in fiber, fermented foods, and antioxidants supports the gut microbiome, which in turn communicates with the skin through the gut-skin axis. When gut inflammation decreases, systemic inflammation declines, creating a more favorable environment for the skin’s own microbial community. This interplay between the gut and skin reveals an essential truth: a healthy microbiome on any part of the body is part of a larger internal ecosystem that sustains overall well-being.
In essence, maintaining microbiome health is not about sterilizing the skin but nurturing it. A thriving microbial community works hand in hand with the lipid matrix of the skin barrier, ensuring long-term stability and defense against both environmental and internal stressors. Recognizing this partnership is crucial to modern skincare science and one of the most powerful shifts in understanding skin health today.
6. Aging and the Skin Barrier: Time’s Subtle Erosion
Aging affects every aspect of the human body, and the skin barrier is no exception. As time passes, the processes that maintain the stratum corneum — cell renewal, lipid synthesis, collagen production, and immune regulation — begin to slow down. The visible signs of aging, such as wrinkles, sagging, and dryness, are not merely surface phenomena; they are reflections of the gradual weakening of the skin barrier’s fundamental structure.
In youth, the skin barrier is robust, flexible, and capable of rapid recovery from damage. The production of ceramides and natural moisturizing factors (NMFs) remains high, ensuring that the stratum corneum stays hydrated and resilient. However, as early as the late twenties, lipid production begins to decline. The decrease in ceramides, fatty acids, and cholesterol leads to increased transepidermal water loss (TEWL), resulting in dryness and dullness. This process is accelerated by environmental factors such as UV exposure, pollution, and smoking, which generate free radicals that damage lipids and proteins within the skin.
Collagen and elastin fibers in the deeper layers also degrade over time due to both intrinsic (genetic) and extrinsic (environmental) aging. This structural weakening not only leads to wrinkles but also reduces the skin’s ability to retain moisture. Moreover, the immune competence of the skin diminishes, making it more prone to inflammation, infection, and delayed wound healing.
Hormonal changes, particularly the decline in estrogen during menopause, play a profound role in skin barrier aging. Estrogen supports the production of hyaluronic acid, collagen, and lipids. When its levels fall, the skin becomes thinner, drier, and less elastic. This explains why post-menopausal women often experience sudden increases in sensitivity, flakiness, or irritation.
While aging is inevitable, the decline of the skin barrier can be significantly mitigated. Regular use of lipid-replenishing products containing ceramides, squalane, and cholesterol helps restore lost structure. Antioxidants like vitamin C, green tea polyphenols, and coenzyme Q10 combat oxidative stress, preventing lipid peroxidation. Retinoids, when used properly, stimulate cell turnover and collagen production, keeping the barrier active and adaptive.
Lifestyle also plays a decisive role in how the barrier ages. Adequate sleep, balanced nutrition, hydration, and sun protection slow down barrier deterioration. Avoiding excessive alcohol and managing stress help maintain hormonal and metabolic balance, both of which are crucial for lipid synthesis and repair.
Ultimately, aging is not merely about the passage of time but about how we support the body’s capacity to repair itself. The skin barrier is a living system that reflects our biological vitality. When nourished and protected, it continues to function efficiently even as the years advance, preserving not only appearance but the essential integrity of our outermost shield.
7. The Science of Recovery: Rebuilding a Damaged Skin Barrier
When the skin barrier becomes compromised — whether through overuse of products, environmental stress, or illness — it requires deliberate and scientifically grounded recovery. Healing the barrier is a process that demands patience and understanding of its biological mechanisms rather than a quick fix.
The first step in recovery is stopping aggravation. Any harsh or unnecessary products should be eliminated. This includes strong acids, alcohol-based toners, high concentrations of active ingredients, and physical exfoliants. The goal during this phase is stabilization, not stimulation. A simplified routine consisting of a gentle cleanser, a soothing moisturizer, and sunscreen allows the barrier to begin its natural repair processes.
At the cellular level, barrier recovery involves the resynthesis of lipids and the restoration of corneocyte cohesion. The lipids — primarily ceramides, cholesterol, and fatty acids — must be replenished in balanced proportions to rebuild the mortar of the “brick-and-mortar” structure. Formulations with a 3:1:1 ratio of these components have been shown in dermatological research to most effectively mimic the skin’s natural lipid organization and accelerate recovery.
Soothing agents such as centella asiatica (cica), panthenol, beta-glucan, and oat extract reduce inflammation and support tissue repair. Meanwhile, niacinamide boosts ceramide production and improves skin elasticity, making it one of the most effective ingredients for long-term barrier strengthening.
Hydration must be approached carefully. While humectants like glycerin and hyaluronic acid attract water to the skin, excessive use without sufficient occlusives can lead to paradoxical dehydration, especially in dry climates. Therefore, layering should always end with a lipid-rich moisturizer or oil to seal in moisture.
Recovery also depends on internal healing. Adequate protein intake supports the production of keratin and structural proteins, while antioxidants counteract inflammation. Supplements such as evening primrose oil (rich in gamma-linolenic acid) and omega-3 fatty acids have demonstrated efficacy in improving barrier function and reducing sensitivity.
Importantly, time is a key factor. The epidermal renewal cycle lasts about 28 days, but barrier recovery may take several cycles, depending on the severity of the damage. Patience and consistency are essential. Attempting to speed up the process with new actives or treatments often backfires, prolonging irritation.
Barrier recovery is not just about reversing damage — it’s about teaching the skin to regain balance. Once healed, the skin often becomes more resilient and less reactive, as its natural repair mechanisms have been reactivated. This adaptive capacity demonstrates that the skin, when respected, possesses an extraordinary ability to regenerate itself.
8. The Future of Skin Barrier Science and Skincare Philosophy
The growing understanding of the skin barrier represents a paradigm shift in dermatology and cosmetic science. The industry is moving away from surface-level beauty ideals and toward a bio-functional approach that prioritizes the health of the barrier as the foundation for all skin concerns. The future of skincare lies not in masking imperfections but in optimizing the biological systems that create true, sustainable beauty.
Cutting-edge research is uncovering the molecular pathways that regulate barrier formation, lipid synthesis, and immune communication. Scientists are exploring epigenetic factors — how lifestyle and environment influence gene expression related to skin repair. These discoveries are paving the way for personalized skincare, where products can be tailored to an individual’s genetic, microbiome, and lifestyle profile.
Emerging technologies are also revolutionizing how we treat the barrier. Biomimetic lipids, for example, replicate the structure of natural ceramides more precisely than ever before, enhancing repair at a molecular level. Probiotic skincare and postbiotic extracts are being engineered to restore microbial balance and reinforce the skin’s innate defense mechanisms. Meanwhile, advancements in skin-on-a-chip and AI modeling allow researchers to test barrier interactions with unprecedented accuracy, reducing reliance on animal testing and improving formulation safety.
The philosophy surrounding skincare is also evolving. The focus is shifting from aggressive transformation to gentle optimization. Consumers are becoming more educated about barrier health, understanding that the goal is not instant perfection but long-term resilience. This movement reflects a broader cultural transition toward wellness, sustainability, and respect for the body’s natural intelligence.
Environmental responsibility is another crucial dimension of the future. The skin barrier’s health is intertwined with the health of the planet. Pollution, climate change, and water scarcity all influence skin physiology. As a result, brands are prioritizing eco-formulations, biodegradable ingredients, and sustainable sourcing, recognizing that caring for the environment ultimately supports the biological balance of human skin.
In the years ahead, the integration of dermatology, nutrition, and biotechnology will continue to blur the lines between health and beauty. Skincare will become less about cosmetics and more about preventive dermatological care — a holistic practice that acknowledges the skin as a living organ system in constant communication with the body and environment.
Ultimately, the future of skin barrier science calls for humility — an acceptance that nature’s design is far more complex and intelligent than any single product or routine. The most advanced skincare philosophy will be one that aligns with, rather than overrides, the body’s innate wisdom. By focusing on balance, nourishment, and sustainability, we not only achieve better skin but also redefine what it means to care for ourselves in harmony with nature.
Conclusion: Beyond the Surface
The obsession with moisturizers, serums, and miracle creams often distracts us from the deeper truth: healthy, beautiful skin is not created on the surface. It is built from within, maintained by the integrity of the skin barrier, and supported by lifestyle choices that promote internal harmony.
The skin barrier is more than just a layer — it is an organ of communication, defense, and resilience. It reflects our internal health and responds dynamically to our environment. When we nourish our bodies, manage stress, and treat our skin gently, we allow this system to perform as nature intended.
A strong skin barrier doesn’t simply look better — it functions better. It resists aging, heals faster, and glows naturally. Moisturizers play an important role, but they are only one piece of the puzzle. The real work happens beneath the surface, inside the skin’s cellular and lipid structures, fueled by nutrition, hydration, and care that begins from the inside out.
In essence, “inside the skin barrier” lies the true secret to lasting skin health. Understanding it transforms the way we see skincare — from a cosmetic ritual to a holistic practice of self-care and biological wisdom. When we respect and protect this natural shield, we don’t just improve our skin — we restore the very foundation of beauty and well-being.
SOURCES
Elias, P. M. (2012). Skin barrier function. Current Allergy and Asthma Reports, 12(1), 96–108.
Madison, K. C. (2003). Barrier function of the skin: “La Raison d’Être” of the epidermis. Journal of Investigative Dermatology, 121(2), 231–241.*
Rawlings, A. V., & Harding, C. R. (2004). Moisturization and skin barrier function. Dermatologic Therapy, 17(S1), 43–48.*
Proksch, E., Brandner, J. M., & Jensen, J. M. (2008). The skin: An indispensable barrier. Experimental Dermatology, 17(12), 1063–1072.*
Lodén, M. (2003). The clinical benefit of moisturizers. Journal of the European Academy of Dermatology and Venereology, 17(6), 587–588.*
Cork, M. J., Danby, S. G., Vasilopoulos, Y., Hadgraft, J., Lane, M. E., Moustafa, M., Guy, R. H., MacGowan, A. L., Tazi-Ahnini, R., & Ward, S. J. (2009). Epidermal barrier dysfunction in atopic dermatitis. Journal of Investigative Dermatology, 129(8), 1892–1908.*
Draelos, Z. D. (2018). The science behind skin care: Moisturizers. Journal of Cosmetic Dermatology, 17(2), 138–144.*
Leung, D. Y. M., & Guttman-Yassky, E. (2014). Deciphering the complexities of atopic dermatitis: Shifting paradigms in treatment approaches. Journal of Allergy and Clinical Immunology, 134(4), 769–779.*
Byrd, A. L., Belkaid, Y., & Segre, J. A. (2018). The human skin microbiome. Nature Reviews Microbiology, 16(3), 143–155.*
Grice, E. A., & Segre, J. A. (2011). The skin microbiome. Nature Reviews Microbiology, 9(4), 244–253.*
Nakatsuji, T., & Gallo, R. L. (2018). The role of the skin microbiome in atopic dermatitis. Annals of Allergy, Asthma & Immunology, 120(6), 603–608.*
Boiten, W., Absalah, S., & Vissers, Y. (2020). Skin barrier and ageing: A review of molecular mechanisms. International Journal of Cosmetic Science, 42(5), 431–440.*
Flament, F., Bazin, R., Laquieze, S., Rubert, V., Simonpietri, E., & Piot, B. (2012). Effect of the sun on visible clinical signs of aging in Caucasian skin. Clinical, Cosmetic and Investigational Dermatology, 5, 199–206.*
Pilkington, S. M., & Rhodes, L. E. (2015). The influence of nutrition on skin aging and barrier function. Clinical Dermatology, 33(3), 313–318.*
Draelos, Z. D. (2021). Skin barrier repair and maintenance in anti-aging skin care. Dermatologic Therapy, 34(2), e14820.*
González, S., & Fernández-Lorente, M. (2010). Aging and the skin: Functional changes. Photodermatology, Photoimmunology & Photomedicine, 26(2), 64–70.*
Boelsma, E., Hendriks, H. F. J., & Roza, L. (2001). Nutritional skin care: Health effects of micronutrients and fatty acids. American Journal of Clinical Nutrition, 73(5), 853–864.*
Danby, S. G., & Cork, M. J. (2010). Lipid replacement therapy for barrier repair in atopic dermatitis. American Journal of Clinical Dermatology, 11(5), 351–364.*
Kim, B. E., Leung, D. Y. M., & Boguniewicz, M. (2020). The role of genetics and environment in atopic dermatitis and barrier dysfunction. Allergy, Asthma & Immunology Research, 12(3), 265–275.*
Zheng, Y., & Ley, R. E. (2022). The microbiome and host skin barrier homeostasis. Trends in Immunology, 43(7), 535–547.*
Kobayashi, T., Glatz, M., Horiuchi, K., Kawasaki, H., Akiyama, H., Kaplan, D. H., & Nagao, K. (2019). Dysbiosis and barrier dysfunction in atopic dermatitis: Mutual influences. Journal of Dermatological Science, 95(1), 18–24.*
Wang, Z., Man, G., Li, T., Elias, P. M., & Man, M. Q. (2020). Aging-associated alterations in epidermal function and their clinical significance. Aging and Disease, 11(5), 1272–1281.*
Pavicic, T., & Wollenweber, U. (2021). Advances in skin barrier restoration: From ceramides to biomimetic lipids. Journal of Cosmetic Dermatology, 20(9), 2823–2833.*
Zouboulis, C. C., & Makrantonaki, E. (2021). Hormonal therapy and skin barrier aging. Dermato-Endocrinology, 13(1), e1911182.*
Yamamoto, A., & Maibach, H. I. (2020). Transepidermal water loss: The signal of barrier damage, repair, and aging. Skin Research and Technology, 26(6), 726–735.*
Moyal, D. (2017). UVA and UVB radiation effects on the skin barrier: Mechanisms and protection. Photodermatology, Photoimmunology & Photomedicine, 33(1), 13–19.*
Kuehne, A., Hildebrand, J., & Kramer, M. (2021). Lipidomics in dermatology: Understanding skin barrier dysfunction. Experimental Dermatology, 30(12), 1738–1749.*
Park, K., & Elias, P. M. (2022). Understanding the epidermal barrier: Molecular basis and clinical implications. Journal of Dermatological Science, 108(2), 68–78.*
HISTORY
Current Version
OCT, 22, 2025
Written By
BARIRA MEHMOOD